Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. They may give you tips on managing a body weight thats healthy for you. Also tell them if you smoke, drink alcohol, or use illegal drugs. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. More than half of American adults take an herbal or dietary supplement, and many more use over-the-counter or prescription drugs to manage maladies ranging from the occasional headache to chronic health conditions or mood disorders.. For many, it is part of their daily routine. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Prolia injection is a brand of denosumab, which treats osteoporosis. If youre concerned about tingling while using Prolia, talk with your doctor. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. Your doctor can also advise you on symptoms of low calcium to look for. Sciatica is described as a shooting pain that travels from the lower back down a leg. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. This information is intended only for U.S. healthcare professionals. Talk with them about your health and any concerns you have about Prolia and its effects. Calcium Supplements: Should You Take Them? - Johns Hopkins Also describe any vitamins, herbs, or supplements you use. However, drinking too much alcohol may raise your risk of falling. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. Calcium and calcium supplements: Achieving the right Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. Whats the Connection Between Estrogen and Osteoporosis? DENOSUMAB (den oh sue mab) slows bone breakdown. Osteoporosis medications and medication-related osteonecrosis of the jaw. It is important for you to practice good mouth care during treatment with Prolia. Prolia pregnancy and breastfeeding warnings. But weight gain may occur with other medications you take or other health conditions you have. Our phase IV clinical studies alone cannot establish cause-effect relationship. The ADA also provides recommendations to help your dentist in reducing your risk for these side effects while youre taking Prolia. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Call your doctor right away if you have signs of infection such as: swelling, pain, tenderness, warmth, or redness anywhere on your body; pain and burning when you urinate, painful urination; bladder infection (painful or difficult urination); lung infection (cough, shortness of breath); cold symptoms such as stuffy nose, sneezing, sore throat; This is not a complete list of side effects and others may occur. When estrogen levels drop, your risk of osteoporosis goes up. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. You can also visit the Prolia manufacturers website to see if they have support options. Let your doctor know if you have questions about which drug is recommended for you. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Theyll discuss with you other treatments to help protect you from fractures and bone loss. Because Prolia can also cause low blood calcium, your risk may increase if you receive Prolia. Like most drugs, Prolia may cause mild or serious side effects. Talk to your health care professional or pharmacist for more information. Continue reading, Yes, Prolia does appear to weaken your immune system. Find out which foods can help. Prolia comes as a solution thats given as an injection under your skin. Osteopenia This is because its not known if Prolia is safe to receive while breastfeeding. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. No, weight gain wasnt reported as a side effect of Prolia in clinical trials. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Prolia (denosumab) | Dosing Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Any advice? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These effects are called interactions. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. For information about the difference between sex and gender, see this article. Others may continue for as long as you take the drug, but they can be easily managed. Do not stop using this medicine without first talking to your doctor. And some of these side effects are more common with certain uses of Prolia. Keep in mind that side effects of a drug can depend on: Additionally, you may experience different side effects from those listed below based on the condition youre treating with Prolia. It may also be higher if you have dental work done while youre taking Prolia. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. You may wonder how Prolia compares with the alternative drug Reclast. Your risk for some health conditions increases when you are postmenopausal. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. Call your doctor for medical advice about side effects. Amount of calcium needed when taking Prolia Is the ketogenic diet right for autoimmune conditions? Some items may interact with your medicine. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. High cholesterol itself doesnt cause any symptoms. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. If you have low calcium levels, you should not take Prolia. These lists dont include all possible side effects. RA is an autoimmune condition in which your immune system attacks your joints. Constipation was also reported as a side effect in females using Prolia for osteoporosis. Cleveland Clinic is a non-profit academic medical center. It strengthens your bones by stopping certain bone cells called osteoclasts from breaking down your bones. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Doctors sometimes prescribe Prolia to treat osteoporosis and bone thinning. Drug class: miscellaneous bone resorption inhibitors. Instead, it belongs to a different group of medications called biologics. No, Prolia isnt a bisphosphonate. Patient testimonials represent individual experiences with Prolia. Prolia has active ingredients of denosumab. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. But doing so can cause more bone breakdown and increase your risk for bone fractures. This helps treat osteoporosis by improving bone mass and strengthening your bones. Be sure to talk with your doctor about your health history before you take Prolia. These types of medications come in forms that are taken by mouth and forms that are given by injection. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Prolia isnt approved to treat osteopenia or arthritis. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What are some frequently asked questions about Prolia? Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. You may have questions about Prolia and your treatment plan. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Prolia Frequently Asked Questions (FAQs) Do any of yall know? (Biologic medications are made from living organisms.). eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. 2023 Healthline Media UK Ltd, Brighton, UK. See additional information. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Q: Does AlgaePlus Increase Bone Mass? We do not endorse non-Cleveland Clinic products or services. Its important to discuss all your concerns with your doctor. Serious side effects of Prolia that have been reported include: For most people, Prolias side effects are mild and go away after a few days to a few weeks. For more information about how these medications compare with each other, ask your doctor. To learn more about this side effect, see Side effect specifics below. Breastfeeding. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply. High cholesterol levels can be a side effect of Prolia. To date, the consensus is that there has been no proven risk of increased cardiovascular risk with intake of calcium supplements. Vitamin D The body needs vitamin D to absorb calcium. But certain choices and habits accelerate the process. (To learn more, see the Precautions for Prolia section below.). * For more information about this side effect, see Side effect specifics below. Your low blood calcium must be treated before you receive Prolia. What osteoporosis medications are there, and what side effects do they have? Last updated on Feb 8, 2023. A biologic drug is made from parts of living organisms. (Biosimilars are like generic drugs. There are no known interactions with Prolia and other medications, supplements, or other products. Prolia should not be used during pregnancy. You may report side effects to FDA at 1-800-FDA-1088. This list doesnt include all possible mild side effects of the drug. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. Stopping Prolia doesnt cause withdrawal symptoms. You may report side effects to FDA at 1-800-FDA-1088. Learn how estrogen affects bone health and how you can protect yourself from bone loss, Osteoporosis is more common in women than men, but it affects millions of men every year. This is not a complete list of warnings for Prolia. Kidney problems. If you keep this medicine at home, store it in the original carton in a refrigerator. Osteoporosis Another common osteoporosis medication is denosumab (Prolia, Xgeva). By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. Web You will receive Prolia 1 time every 6 months. You should also talk with them if you have any serious side effects during Prolia treatment. You will receive your Prolia injection from your healthcare provider at a their office or clinic. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Store in the original container away from heat and light. (2021). If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. Follow your doctor's instructions. Yoga is an excellent way to manage symptoms of osteoporosis. But its not clear how often this side effect occurred in clinical trials. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Prolia can also cause low calcium levels. And theyll recommend if its the best option for your condition. If youd like a detailed comparison of Prolia versus Boniva, view this article. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. And they want you to get the best care possible. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Serious side effects from Prolia can occur, but they arent common. Nausea can sometimes be a symptom of severe constipation. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. If your levels are high, theyll typically recommend lifestyle changes and medication. To learn more about these two drugs, check out this drug article. If you receive Prolia, you should not receive XGEVA. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Prolia is a monoclonal antibody. You might be interested in seeing how Prolia and the drug Boniva compare. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Calcium Supplements It is often used in osteoporosis. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. for prostate cancer that has not spread to other parts of the body. Calcium has active ingredients of calcium. Both are prescription medicines. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Prolia can cause both mild and serious side effects. Take only the amount of calcium and vitamin D that your doctor has prescribed. Patients in the study may take other drugs besides Prolia and Calcium. This is because the drug may be harmful to a growing fetus. They can also suggest ways to relieve this side effect. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin Its given to adults who are at high risk for bone fractures. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Prolia may be used off-label for RA, if you have a high risk for bone fractures. Learn how to slow it down and fortify your body against it. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. You may be interested in learning how Prolia compares to the medication Fosamax. Talk with your doctor about the risks of using this drug during pregnancy. What should be considered before taking Prolia? Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. You do not give Prolia to yourself. They can treat the infection as needed. Your doctor will recommend the dosage of Prolia thats right for you. Prolia (denosumab) injection, for subcutaneous use. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Prolia Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. It could harm the unborn baby or cause birth defects. These include osteonecrosis of the jawbone. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. Over time, Prolia can reduce bone loss and make your bones stronger. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. If youve already gone through menopause, your risk for bone loss is increased. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. Call your doctor for medical advice about side effects. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. Can diet help improve depression symptoms? Talk with your doctor about the best options for treating your condition. If you develop hypocalcemia, your doctor will typically have you stop using Prolia. Yes, if recommended by your doctor, you can stop taking Prolia. Do not use denosumab if you are pregnant. Some people may have dental or jaw-related issues with Prolia use. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. You should not breastfeed while using this medicine. WebDrug interactions are reported among people who take Prolia and Calcium. To learn more about this, see the How is Prolia administered? section below. But Zometa contains the active drug zoledronic acid. If you have any questions about Prolias side effects, talk with your doctor. Pregnancy. Prolia contains the active ingredient denosumab. This could include having: Before taking Prolia, share your dental history with your doctor. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison.
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